Opinion Article - (2023) Volume 10, Issue 4

Emerging strategies in urological reconstruction for prune belly syndrome

Casey Lee*
*Correspondence: Casey Lee, Department of Urology, University of Pisa, Pisa, Italy, Email:

Author info »


Prune Belly Syndrome (PBS), also known as Eagle- Barrett syndrome, is a rare congenital disorder that primarily affects male infants. It is characterized by a triad of anomalies: abdominal wall muscle deficiency, urinary tract abnormalities, and undescended testicles. Among these, the urological complications are often the most challenging to manage. Before delving into the emerging strategies, it’s essential to grasp the complexity of Prune Belly Syndrome’s urological aspect. In PBS, urinary tract abnormalities are prevalent and can range from Vesico Ureteral Reflux (VUR) to hydronephrosis, hydroureter, and megaureter. These conditions put patients at risk of urinary tract infections, renal deterioration, and eventual renal failure. Managing these challenges requires a multidisciplinary approach and innovative solutions.

One of the crucial steps in managing PBS is early diagnosis and assessment of urinary tract anomalies. Advances in urological imaging have been instrumental in achieving this. High-resolution ultrasound, Computed Tomography (CT) scans, and Magnetic Resonance Imaging (MRI) provide detailed insights into the urinary tract’s structure and function, enabling precise planning for reconstruction surgeries. Robotic-assisted surgery has revolutionized urological reconstruction for PBS patients. The enhanced precision and visualization offered by robotic systems have significantly improved surgical outcomes. Procedures such as pyeloplasty, ureteral reimplantation, and bladder augmentation can be performed with greater accuracy and minimal invasiveness, reducing postoperative pain and recovery times.

Each PBS case is unique, necessitating a tailored approach to urological reconstruction. Surgeons now use 3D printing technology to create patient-specific models of the urinary tract, allowing them to plan and rehearse complex procedures before the actual surgery. This level of customization enhances the surgeon’s ability to address the specific anatomical challenges posed by PBS. Bladder dysfunction is a common issue in PBS, often requiring augmentation cystoplasty to increase the bladder’s capacity and compliance. Emerging techniques involve using tissue-engineered scaffolds and regenerative medicine approaches to create functional bladder tissue. These innovations aim to provide long- term relief from urinary incontinence and reduce the need for catheterization.

Preserving renal function is of paramount importance in PBS. Nephron-sparing surgeries, such as partial nephrectomy and nephroureterectomy, are increasingly considered as alternatives to complete nephrectomies. These procedures aim to remove only the non-functioning or severely damaged renal tissue while sparing as much healthy kidney tissue as possible, thus reducing the risk of renal insufficiency. Recent studies have explored the potential of stem cell therapies in PBS urological reconstruction. Mesenchymal Stem Cells (MSCs) have  shown promise in regenerating damaged urinary tract tissues. Clinical trials are underway to evaluate the safety and efficacy of MSC-based therapies in improving urinary function and reducing the need for surgical interventions.

Urological reconstruction for Prune Belly Syndrome (PBS) in children is a critical aspect of managing this complex congenital condition. PBS typically involves abdominal muscle deficiency, undescended testes, and severe urinary tract anomalies. Surgery can increase bladder capacity and compliance, reducing the risk of recurrent urinary tract infections and preserving renal function. Correcting undescended testes is essential to promote fertility and optimize cosmetic appearance. Repairing or repositioning the ureters is often necessary to improve urinary drainage and prevent kidney damage.

In some cases, abdominal wall repair may be needed to improve abdominal muscle function and appearance. Surgical techniques like bladder neck reconstruction or the creation of a catheterizable channel can help achieve urinary continence. Long-term monitoring  is crucial to assess renal function and manage any potential complications. Urological reconstruction in pediatric PBS aims to enhance the child’s quality of life, prevent renal impairment, and optimize urinary and reproductive health, often requiring a multidisciplinary approach involving urologists, pediatric surgeons, and other specialists.


In conclusion, Prune Belly Syndrome presents a complex array of urological challenges in affected children. However, with the emergence of advanced imaging techniques, minimally invasive surgeries, stem cell therapies, and customized approaches, there is growing optimism in improving the quality of life for PBS patients. These emerging strategies, along with a multidisciplinary care model and long-term follow-up, offer hope for better outcomes and a brighter future for those born with this rare condition. As research continues to advance, the field of pediatric urology is poised to make further breakthroughs in the reconstruction and management of Prune Belly Syndrome.

Author Info

Casey Lee*
Department of Urology, University of Pisa, Pisa, Italy

Received: 28-Jul-2023, Manuscript No. PUCR-23- 112996; , Pre QC No. PUCR-23- 112996 (PQ); Editor assigned: 01-Aug-2023, Pre QC No. PUCR-23- 112996 (PQ); Reviewed: 15-Aug-2023, QC No. PUCR-23- 112996; Revised: 22-Aug-2023, Manuscript No. PUCR-23- 112996 (R); Published: 29-Aug-2023, DOI: 10.14534/j-pucr.20222675600

Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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